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OALib Journal期刊

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Maxillary sinus augmentation procedures through equine-derived biomaterial or calvaria autologous bone: immunohistochemical evaluation of OPG/RANKL in humans
S. Tetè,R. Vinci,V.L. Zizzari,S. Zara
European Journal of Histochemistry , 2013, DOI: 10.4081/ejh.2013.e10
Abstract: Autologous bone is considered the gold standard for bone regeneration, even if different heterologous bone substitutes have been proposed to overcome the limits related to its use. The aim of this study was to analyze and to compare the molecular events switched on by autologous or heterologous bone graft insertion, focusing on TGFβ1 expression and OPG/RANKL ratio, to analyze resorption process, and estimating graft vascularization, new bone tissue deposition and its mineralization, through VEGF, BSP and SPARC expression evaluation, respectively. Patients needing pre-prosthetic rehabilitation of the posterior maxilla were treated using an equine-derived biomaterial (Group 1) or calvaria autologous bone (Group 2), according to the morphology of the bone defect. Bone graft integration was evaluated on bone samples obtained from the treated areas at the moment of dental implant insertion, by morphological and immunohistochemical analyses for TGFβ1, OPG, RANKL, VEGF, BSP, and SPARC expression. Morphological analysis shows the presence of biomaterial residual granules in Group 1, in parallel to a good integration between graft and host tissue. Moderate TGFβ1 expression is seen in both Group 1 and Group 2. OPG/RANKL ratio appear higher in Group 1; VEGF expression appears very strong in Group 1 and strong in Group 2, while BSP and SPARC expression results weak in Group 1 and moderate in Group 2. Results reveal the good integration between both types of graft and the host tissue, even though autologous graft seems to produce a faster regenerative process, as evidenced by the different expression of the investigated molecules. According to these observations, the clinical use of heterologous particulate equine-derived biomaterial may ensure long-term predictability of implant-prosthetic rehabilitation, comparable to that obtained with autologous bone graft.
A Compact, Versatile Six-Port Radar Module for Industrial and Medical Applications
Sarah Linz,Gabor Vinci,Sebastian Mann,Stefan Lindner,Francesco Barbon,R. Weigel,Alexander Koelpin
Journal of Electrical and Computer Engineering , 2013, DOI: 10.1155/2013/382913
Abstract: The Six-port receiver has been intensively investigated in the last decade to be implemented as an alternative radar architecture. Plenty of current scientific publications demonstrate the effectiveness and versatility of the Six-port radar for special industrial, automotive, and medical applications, ranging from accurate contactless vibration analysis, through automotive radar calibration, to remote breath and heartbeat monitoring. Its highlights, such as excellent phase discrimination, trivial signal processing, low circuit complexity, and cost, have lately drawn the attention of companies working with radar technology. A joint project involving the University of Erlangen-Nuremberg and InnoSenT GmbH (Innovative Sensor Technology) led to the development of a highly accurate, compact, and versatile Six-port radar module aiming at a reliable high-integration of all subcomponents such as antenna, Six-port front-end, baseband circuitry, and digital signal processing in one single package. Innovative aspects in the RF front-end design as well as in the integration strategy are hereby presented, together with a system overview and measurement results. 1. Introduction Optical high-resolution, contactless distance measurement techniques such as laser interferometry and laser pulse time-difference measurements have been widely implemented for industrial and medical applications. The drawback of optical techniques is the difficulty to penetrate dust and fog with the laser in harsh environments as optical lenses and mirrors can get dirty. Furthermore, with increasing suspended particle density in the propagation environment dampening and scattering effects increase so that the laser cannot reach the surface of the object under investigation. These inconveniences of laser based systems are the cause of an increasing interest in alternative nonoptical measurement techniques that are robust against such industrial environment conditions. One of the main noncontact-based alternatives to laser is radar. Radar-based measurement techniques work also when a direct optical line of sight to the object under investigation is not guaranteed since radar waves can propagate much better through foggy or dusty air. Furthermore, even bulky and optically nontransparent dielectric slabs or nonmetallic shields can be penetrated by the radar signal [1, 2]. Within the last decade, radar technology has been rapidly expanding in industrial, automotive, and medical application areas [3]. Advanced positioning and sensor feedback tasks in automation processes rely on high precision
WT1 expression in the human fetus during development | European Journal of Histochemistry
A. Faa,C. Gerosa,D. Fanni,E. Obinu,L. Vinci,R. Ambu,V. Fanos
- , 2015, DOI: https://doi.org/10.4081/ejh.2015.2499
Abstract: Wilmsa€？ Tumor 1 (WT1) is a transcription factor involved in the development of the urogenital system. The purpose of this study was to analyze the immunoreactivity for WT1 protein in different tissues and organs in human fetuses in early phases of gestation. To this end, samples from multiple organs were obtained from 4 human fetuses, ranging from 7 up to 12 weeks of gestation. Each sample was formalin-fixed, paraffin embedded and immunostained for WT1. Our data show that WT1 is involved in development of multiple human organs in a more vast series of cells types than previously reported. Immunostaining for WT1 was characterized by a predominant cytoplasmic reactivity in the vast majority of cell types. Mesenchimal progenitors in the fetal lung, ductal plate progenitors in fetal liver, cap mesenchimal cells in the developing kidney, fetal zone cells in adrenal glands, atrial and ventricular cardiomyocytes in the fetal heart, radial glial cells in the fetal cerebral cortex and skeletal muscle cell precursors showed the highest levels of WT1 immunoreactivity. Future studies will be needed to detect differences in the expression of WT1 in various organs at different gestational ages, in order to better evaluate the role of WT1 in cell proliferation and differentiation during intrauterine human development
Post extractive implant: evaluation of the critical aspects
A. TAGLIABUE,C. ANDRISANI,J. SILVESTRE-RANGIL,L. TETTAMANTI,M. ANDREASI BASSI,R. VINCI
- , 2017, DOI: 10.11138/orl/2017.10.2.119
Abstract: Nowadays, implant supported prosthetic rehabilitation is a reliable procedure to replace compromised or untreatable teeth. The purpose of this review is to explore the concept of post extractive implant and the indications for clinical practice through an analysis of recent studies in the literature. All the main factors that could influence the outcome of this treatment will also be considered
Immediate loading implants: review of the critical aspects
A. TAGLIABUE,C. ANDRISANI,J. SILVESTRE-RANGIL,L. TETTAMANTI,M. ANDREASI BASSI,R. VINCI
- , 2017, DOI: 10.11138/orl/2017.10.2.129
Abstract: Modern dentistry have witnessed, a rapid and continuing evolution. Concerning the implant-rehabilitation protocols, they have been redefined in order to satisfy patient’s increasing expectations in terms of comfort, aesthetic and shorter treatment period. The purpose of this review is to explore the concept of implant immediate loading and the indications for clinical practice. All the critical aspects that could influence the outcomes of this treatment will also be considered
A ordem do livro e outros textos: (35 fólios em fac-símile da Cole o do Castelo de Windsor)
Leonardo da Vinci
Scientiae Studia , 2011, DOI: 10.1590/s1678-31662011000200006
Abstract:
Non-Abelian Monopoles in the Higgs Phase
Muneto Nitta,Walter Vinci
Physics , 2010, DOI: 10.1016/j.nuclphysb.2011.02.014
Abstract: We use the moduli matrix approach to study the moduli space of 1/4 BPS kinks supported by vortices in the Higgs phase of N = 2 supersymmetric U(N) gauge theories when non-zero masses for the matter hypermultiplets are introduced. We focus on the case of degenerate masses. In these special cases vortices acquire new orientational degrees of freedom, and become "non-Abelian". Kinks acquire new degrees of freedom too, and we will refer to them as "non-Abelian". As already noticed for the Abelian case, non-Abelian kinks must correspond to non-Abelian monopoles of the unbroken phase of SU(N) Yang-Mills. We show, in some special cases, that the moduli spaces of the two objects are in one-to-one correspondence. We argue that the corre- spondence holds in the most general case. The consequence of our result is two-fold. First, it gives an alternative way to construct non-Abelian monopoles, in addition to other well- known techniques (Nahm transform, spectral curves, rational maps). Second, it opens the way to the study of the quantum physics of non- Abelian monopoles, by considering the simpler non-Abelian kinks.
Nei labirinti narrativi di Calvino e Eco: enciclopedia, “romanzo totale” e vocazione cosmica della letteratura
Maria Gloria Vinci
- , 2015, DOI: https://doi.org/10.5007/2175-7917.2015v20nesp1p75
Abstract: Sempre in bilico e in tensione dialettica tra ordine e caos, cosmo e frammento, apertura e chiusura, ricerca del codice totale e abbandono decostruttivo, Calvino e Eco riconoscono entrambi il potenziale creativo e conoscitivo della letteratura, la capacità di aprirsi direttamente sulla multiforme variabilità del mondo e di registrare e interpretare il carattere caleidoscopico delle nostre esperienze e dei nostri linguaggi. Se la letteratura pretende mappare l’intrico del dedalo del mondo contemporaneo e farsi mimesi della sua complessità e totalità culturale, essa non può che avere, sia per Calvino come per Eco, se non una vocazione cosmica, ？al livello dei piani di conoscenza che lo sviluppo storico ha messo in gioco？ (CALVINO, 2011a, p. 119). Nel tracciare le linee di una letteratura universale dalla vocazione cosmologica, entrambi pensano che dal ménage à trois della letteratura con la scienza e la filosofia, si possa trarre una nuova strategia di osservazione, un del tutto mutato sguardo da gettare sulle cose e sul mondo. In questo senso essi si riallacciano a quella tradizione letteraria, che porta in sé, fin dalle sue origini moderne, una vocazione enciclopedica e concepisce il romanzo come opera totale. Si tratta dell′audace e velleitario tentativo di scrivere il Libro assoluto, enciclopedia rizomatica e rete di connessioni infinite, clavis universalis che, secondo Mallarmé, permette di collegare Poesia e Universo. Pertanto, in questa ottica, i concetti e le metafore di romanzo totale, labirinto, biblioteca, enciclopedia, nonché le strategie retoriche e cognitive quali la tecnica combinatoria, l′enumerazione e la lista, presi in considerazione in questo intervento, assumono una loro coerenza, all′interno di un progetto letterario che aspira alla totalità, nel tentativo di ricomporre una unità perduta e tracciare una storia universale del mondo. Impresa inane e destinata al fallimento, tuttavia. Ogni progetto di organizzare l′esperienza in un esaustivo catalogo sapienziale rivela la sua illusorietà: per dirla con Eco, “l’Universo semantico globale” resta un concetto-limite o, meglio, “un postulato semiotico” che non può essere mai rappresentato nella sua interezza
Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex | European Journal of Histochemistry
A. Ravarino,A.G. Naccarato,C. Gerosa,G. Bevilacqua,G. Faa,G. Senes,L. Vinci,R. Ambu,V. Fanos
- , 2016, DOI: https://doi.org/10.4081/ejh.2016.2563
Abstract: The development of the human central nervous system represents a delicate moment of embryogenesis. The purpose of this study was to analyze the expression of multiple immunohistochemical markers in the stem/progenitor cells in the human cerebral cortex during the early phases of development. ？ To this end, samples from cerebral cortex were obtained from 4 human embryos of 11 weeks of gestation. Each sample was formalin-fixed, paraffin embedded and immunostained with several markers including GFAP, WT1, Nestin, Vimentin, CD117, S100B, Sox2, PAX2, PAX5, T？24, Neurofilament, CD44, CD133, Synaptophysin and Cyclin D1. Our study shows the ability of the different immunohistochemical markers to evidence different zones of the developing human cerebral cortex, allowing the identification of the multiple stages of differentiation of neuronal and glial precursors. Three important markers of radial glial cells are evidenced in this early gestational age: Vimentin, Nestin and WT1. Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE. Future studies are needed to test other important stem/progenitor cells markers and to better analyze differences in the immunohistochemical expression of these markers during gestation
Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI
Chris Jones,Gary Box,Jessica K.R. Boult,Lara Perryman,Maria Vinci,Simon P. Robinson,Suzanne A. Eccles
- , 2017, DOI: 10.1016/j.neo.2017.05.007
Abstract: Vascular endothelial growth factor A (VEGF-A) is considered one of the most important factors in tumor angiogenesis, and consequently, a number of therapeutics have been developed to inhibit VEGF signaling. Therapeutic strategies to target brain malignancies, both primary brain tumors, particularly in pediatric patients, and metastases, are lacking, but targeting angiogenesis may be a promising approach. Multiparametric MRI was used to investigate the response of orthotopic SF188luc pediatric glioblastoma xenografts to small molecule pan-VEGFR inhibitor cediranib and the effects of both cediranib and cross-reactive human/mouse anti-VEGF-A antibody B20-4.1.1 in intracranial MDA-MB-231 LM2–4 breast cancer xenografts over 48 hours. All therapeutic regimens resulted in significant tumor growth delay. In cediranib-treated SF188luc tumors, this was associated with lower Ktrans (compound biomarker of perfusion and vascular permeability) than in vehicle-treated controls. Cediranib also induced significant reductions in both Ktrans and apparent diffusion coefficient (ADC) in MDA-MB-231 LM2–4 tumors associated with decreased histologically assessed perfusion. B20-4.1.1 treatment resulted in decreased Ktrans, but in the absence of a change in perfusion; a non-significant reduction in vascular permeability, assessed by Evans blue extravasation, was observed in treated tumors. The imaging responses of intracranial MDA-MB-231 LM2–4 tumors to VEGF/VEGFR pathway inhibitors with differing mechanisms of action are subtly different. We show that VEGF pathway blockade resulted in tumor growth retardation and inhibition of tumor vasculature in preclinical models of pediatric glioblastoma and breast cancer brain metastases, suggesting that multiparametric MRI can provide a powerful adjunct to accelerate the development of antiangiogenic therapies for use in these patient populations
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